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![]() ![]() True right-to-left shunting of mixed venous blood can occur through the lungs (intrapulmonary shunt) or across the atrial septum (intracardiac shunt). Consequently, some lung units are overventilated relative to perfusion (increased dead space), while other lung units are underventilated relative to perfusion (venous admixture). ![]() Acute pulmonary thromboembolism also disturbs matching of ventilation and blood flow. Vasoconstriction, either reflexly or biochemically mediated, may contribute to increased pulmonary vascular resistance. For patients without preexistent cardiopulmonary disease, increased pulmonary vascular resistance is directly related to the degree of vascular obstruction demonstrated on the pulmonary arteriogram. ![]() Foremost among these alterations is increased pulmonary vascular resistance. Acute pulmonary thromboembolism produces a number of pathophysiologic derangements of pulmonary function. ![]()
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